Toxicological_Abbreviations - Herbdata New Zealand

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Toxicological Abbreviations
May 1998

AA activation analysis; atomic absorption AAF acetylaminofluorene AAPCC American Association of Poison Control Centers AAS atomic absorption spectrophotometry ABS acrylonitrile-butadiene-styrene ACE angiotensin-converting enzyme ACGIH American Conference of Governmental Industrial Hygienists ACh acetylcholine AChE acetylcholinesterase AcP acid phosphatase ACTH adrenocorticotropic hormone AD Alzheimer’s disease ADH alcohol dehydrogenase; anti-diuretic hormone ADI acceptable daily intake ADP adenosine diphosphate AEP auditory evoked potential AES atomic emission spectroscopy AFID alkali flame ionization detection Ah aromatic hydrocarbon AHH aryl hydrocarbon hydroxylase ai active ingredient AIDS acquired immune deficiency syndrome AIN acute interstitial nephritis ALA aminolevulinic acid ALAD ²-aminolaevulinic acid dehydratase ALAS o-aminolevulinic acid synthetase ALAT alanine aminotransferase ALC approximate lethal concentration ALD approximate lethal dose ALMS atomic line molecular spectrometry ALT alanine aminotransferase AM alveolar macrophages AMP amperometric titration AMPA aminomethylphosphonic acid ANTU alpha-naphthylthiourea AP alkaline phosphatase APDM aminopyrine-N-demethylase APP ammonium polyphosphate AQG Air Quality Guidelines ARF acute renal failure ARL acceptable or tolerable residue limit ART alternate reproductive test ASAT aspartate aminotransferase ASV anodic stripping voltametry ATA alimentary toxic aleukia ATH alumina trihydrate ATPase adenosine triphosphatase AUC area under the curve AWI acceptable or tolerable weekly intake

B bursa-dependent BA 2-bromoacrolein BAER brainstem auditory-evoked response BAF bioaccumulation factor BAL bronchoalveolar lavage BBB blood-brain barrier BBPP bis(2,3-dibromopropyl) phosphate BCF bioconcentration factor BEA 2-bromoethylamine BEI biological exposure index BEN Balkan endemic nephropathy BGG bovine gammaglobulin BHA butylated hydroxyanisole BHK baby hamster kidney BIC butyl isocyanate BMAA beta-N-methylamino-L-alanine BMD benchmark dose (US EPA) BMF biomagnification factor BOAA beta-N-oxalylamino-L-alanine BOD biochemical oxygen demand BP benzo[a]pyrene BSA bovine serum albumin BSP bromosulfophthalein BUB 2-(3-butylureido)benzimidazole BUN blood urea nitrogen bw body weight C CA chrysanthemic acid CALLA common acute lymphoblastic leukaemia antigen cAMP cyclic adenosine monophosphate CAS Chemical Abstracts Service CBF cerebral blood flow CC critical concentration CCFA Codex Committee on Food Additives (see definition of Codex Alimentarious Commission) CCPR Codex Committee on Pesticide Residues CCTTE Computerized Listing of Chemicals Being Tested for Their Toxicological Effects (IPCS/IRPTC) CD cluster of differentiation; coulometric detection cDNA complementary DNA CE capillary electrophoresis CEC Commission of the European Communities CEFIC European Council of Chemical Industry Federations CFC chlorofluorocarbon cGMP cyclic guanosine monophosphate ChE cholinesterase CHO Chinese hamster ovary Ci curie(s) CI confidence interval CIN chronic interstitial nephritis CKSCC cystic keratinizing squamous cell carcinoma Cl_2 CA 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid CLD chemiluminescence nitrogen detector CLM chemiluminescence method CLV ceiling value Cl-Vacid (= CPIA) 2-(4-chlorophenyl)isovaleric acid CMI cell-mediated immunity CML cell-mediated lympholysis CNS central nervous system COD chemical oxygen demand CO-Hb carboxyhaemoglobin COPD chronic obstructive pulmonary disease COT Committee on Toxicity (United Kingdom) cP centipoise(s) CP coproporphyrins CPA cyclopropane carboxylic acid CPK creatine phosphokinase CRMs certified reference materials CSF cerebrospinal fluid CSM Committee on Safety of Medicines (United Kingdom) CT computerized tomography cv coefficient of variation

2,4-D 2,4-dichlorophenoxyacetic acid DAB 4-dimethylaminobenzene DABA L-2,4-diaminobutyric acid DBCP 1,2-dibromo-3-chloropropane DBP

di-n-butyl phthalate; 2,3-dibromopropanol

DBT dibutyltin DCB dichlorobenzene DCVC S-(1,2-dichlorovinyl)-L-cysteine DDC diethyldithiocarbamate DDT dichlorodiphenyltrichloroethane DEHP diethylhexyl phthalate DEN diethylnitrosamine DES diethylstilbestrol DFB diflubenzuron DFP diisopropylfluorophosphate (a delayed neurotoxic) DHPN N-bis(2-hydroxypropyl) nitrosamine DiBP di-iso-butyl phthalate DIDT 5,6-dihydro-3H-imidazo (2,1-C)-1,2,4-dithiazole-3-thione DIT diiodotyrosine DL detection limit DMA dimethylamine DMBA dimethylbenzathraline DMF dimethylformamide DMP dimethylphenol DMSO dimethyl sulfoxide DNA deoxyribonucleic acid DNCB dinitrochlorobenzene DNPH 2,4-dinitrophenyl hydrazine DOC dissolved organic carbon DPASV differential pulse anodic stripping voltametry DPTA degradation time for 50% of a compound DTPA diethylenetriamine pentaacetic acid E EBDC ethylene bisdithiocarbamate EBK ethyl n-butyl ketone EC effective concentration; electron capture; emulsifiable concentrate EC_50 median effective concentration ECD electron capture detection ECETOC European Chemical Industry Ecology and Toxicology Centre ECG electrocardiogram ECMO extracorporeal membrane oxidation ECOD 7-ethoxycoumarin-o-deethylase EDA ethylenediamine; exploratory data analysis EDB 1,2-dibromoethane (ethylene dibromide) EDCF endothelial-derived contracting factor EDI ethylene diisothiocyanate EDL electrode discharge lamp EDTA ethylenediaminetetraacetic acid 2-EE 2-ethoxyethanol 2-EEA 2-ethoxyethyl acetate EEC European Economic Community; electroencephalograph EEG electroencephalogram EGF epidermal growth factor EH epoxide hydratase EHC Environmental Health Criteria EI electron impact EIFAC European Inland Fisheries Advisory Commission of FAO ELISA enzyme-linked immunosorbent assay EMDI estimated maximum daily intake EMG electromyography EMTD estimated maximum tolerated dose ENG electroneurography ENL erythema nodosum leprosum ENU ethylnitrosourea EP electrophoresis EPA Environmental Protection Agency (USA) EPDM ethylene propylene rubber EPI exposure/potency index EPS expandable polystyrene EQC external quality control EQT environmental quality target ERL extraneous residue limit EROD 7-ethoxyresurofin-o-deethylase ESCA electron spectroscopy for chemical analysis ESR erythrocyte sedimentation rate ESRD end-stage renal disease ETA electrothermal atomization ETD ethylene bisthiuram disulfide ETG epidermal transglutaminase ETU ethylenethiourea ETV electrothermal vaporization EU ethyleneurea F F_0 parental generation F_1 filial generation, first F_2 filial generation, second FAA flameless atomic absorption FACS fluorescence activated cell sorter FAD flavin adenine dinucleotide FCAT Freund’s complete adjuvant test f.c. Field capacity FD fluorescence detection FDA Food and Drug Administration (USA) FEF forced expiratory flow FEP free erythrocyte porphyrin FEV forced expiratory volume fg femtogram (10^-15 g) FI flame ionization FID flame ionization detector FMLP formyl methionyl leucyl phenylalanine FMN flavin mononucleotide FOB functional observational battery FPD flame photometric detector FR flame retardant FS fluorescence spectrophotometry FSC Food Safety Council (USA) FSD flame photometric detector selective for sulfur FSH follicle-stimulating hormone FTIR Fourier transform infrared FVC forced vital capacity G GA gibberillic acid GABA gamma-aminobutyric acid GAG glycosaminoglycan GALT gut-associated lymphoid tissue GAP good agricultural practice GBM glomerular basement membrane GC gas chromatography GC-ECD gas chromatography with electron capture detector GDH glutamate dehydrogenase GDMS glow discharge mass spectrometry GEMS Global Environmental Monitoring System GESAMP Group of Experts for the Scientific Aspects of Marine Pollution GFAAS graphite furnace atomic absorption spectrometry GFR glomerular filtration rate GGT gamma-glutamyltranspeptidase GH growth hormone GI gastrointestinal GIFAP International Group of National Association of Manufacturers of Agrochemical Products
(French Acronym for: Groupement International des Associations Nationales de Fabricants de Produits Agrochimiques) GLC gas-liquid chromatography GLDH glutamate dehydrogenase GLP good laboratory practice cGMP cyclic guanosine monophosphate GOT glutamic-oxaloacetic transaminase GPC gel permeation chromatography GPMT guinea-pig maximization test GPT glutamic-pyruvic transaminase GS glutamine synthetase GSH glutathione-SH GST glutathione-S-transferase GTB glomerular tubular balance GV guidance value GWP global-warming potential H h hour(s) ha hectare Hb haemoglobin HBCD hexabromocyclododecane HBDH hydroxybutyric dehydrogenase H & E haematoxolin and eosin HCB hexachlorobenzene HCBD hexachloro-1,3-butadiene HCFC hydrochlorofluorocarbon HCFH-22 chlorodifluoromethane (CHClF_2 ) HCG human chorionic gonadotropin HCH hexachlorocyclohexane HDL high density lipoprotein HDPE high density polyethylene HEAL Human Exposure Assessment Location HECD Hall electron capture detector HEV high endothelial venule HEX hexachlorocyclopentadiene HGPRT hypoxanthine-guanine phosphoribosyltransferase HIPS high impact polystyrene HIV human immunodeficiency virus HLB hydrophilic-lipophilic balance HLV hygienic limit value hnRNA heterogeneous nuclear RNA HPCA human progenitor cell antigen HPI cyclohexane-1,2-dicarboximide HPLC high-performance liquid chromatography HPTLC high-performance thin-layer chromatography HQ hydroquinone HS headspace HSA heat-stable antigen; human serum albumin HSG Health and Safety Guide I IARC International Agency for Research on Cancer IC ion chromatography ICAM intercellular adhesion molecule IC_50 median inhibitory concentration ICD International Classification of Diseases ICG indocyanine green ICP inductively coupled plasma ICST isolated cold stress testing i.d. internal diameter IDMS isotope dilution mass spectrometry IFN interferon Ig immunoglobulin IL interleukin ILO International Labour Organisation ILSI International Life Science Institute im intramuscular ip intraperitoneal IPA isopropylamine IPCS International Programme on Chemical Safety IQ intelligence quotient IQC internal quality control IR infrared IRPTC International Register of Potentially Toxic Chemicals ISO International Organization for Standardization IT isomeric transition IU international unit IUPAC International Union of Pure and Applied Chemistry iv intravenous J JECFA Joint FAO/WHO Expert Committee on Food Additives JMPR Joint FAO/WHO Meeting on Pesticide Residues K kcal kilocalorie(s) keV kiloelectronvolt(s) K_ow octanol/water partition coefficient L LAP leucine aminopeptidase LAQL lowest analytically quantifiable level LC liquid chromatography LC_50 median lethal concentration LD_01 lethal dose for 1% LD_50 median lethal dose LDH lactate dehydrogenase LDL low density lipoprotein LDPE low density polyethylene LDQ lowest detectable quantity LEI lifetime exposure intensity LEV local exhaust ventilation Lf limit flocculation LFA lymphocyte function-related antigen LFP lavage fluid protein LH luteinizing hormone LI labelling index LIF laser-induced fluorescence; leukaemia inhibitory factor LLD lowest lethal dose LMS linear multistage model LMW low molecular weight LOAEL lowest-observed-adverse-effect level LOD limit of determination LOEL lowest-observed-effect level LRNI lower reference nutrient intake (UK) LSC liquid scintillation counter LT_50 median lethal time LTP long-term potentiation M MAA methoxyacetic acid MAC maximum allowable concentration MAD maximum allowable deviation MAFF Ministry of Agriculture, Forestry and Fisheries (Japan) MAK maximum workplace concentration (Maximale Arbeitsplatzkonzentration) MALT mucosa-associated lymphoid tissue MAM methylazoxymethanol MAP mutagenic activity profile MAOI monoamine oxidase inhibitor MARC Monitoring and Assessment Research Centre (UK) MARE monoclonal anti-rat immunoglobulin E MAS molecular absorption spectrometry MAT mean absorption time MATC maximum acceptable toxicant concentration MBC minimum bactericidal concentration MBDE mass balance differential equation MBK methyl n-butyl ketone MBP monobutyl phthalate MBT monobutyltin MC methyl chloroform 3-MC 3-methylcholanthrene MCD microcoulometric detection MCH mean cell haemoglobin MCHC mean cell haemoglobin concentration mCi millicurie MCL melanotic cell lines MCPA 4-chloro-o-tolyoxyacetic acid MCV mean cell volume MDA malondialdehyde MDI methylene-diphenyl diisocyanate MDMA methylenedioxymethamphetamine 2-ME 2-methoxyethanol 2-MEA 2-methoxyethyl acetate MeB_12 methylcobalamin MED minimum effective dose; minimal erythemal dose MEHP monoethylhexyl phthalate MEK methyl ethyl ketone mEq milliequivalent MeV megaelectronvolt(s) MFO mixed-function oxidase MHC major histocompatibility complex MHW Ministry of Health and Welfare (Japan) MIBK methyl isobutyl ketone MIC minimal inhibitory concentration MIT methylisothiocyanate; monoiodotyrosine MLD minimum lethal dose MLR mixed lymphocyte response assay MLSS mixed liquor suspended solids MMA methoxyacetic acid MMAD mass median aerodynamic diameter MMH monomethylhydrazine mmHg millimetre(s) of mercury MMMF man-made mineral fibre MNNG N-methyl-N -nitro-N-nitrosoguanidine MNU N-methyl-N-nitrosurea mPa millipascal (7.5 x 10^-6 mmHg) MPC maximum permissible limit MQL minimum quantifiable limit MRBIS mean running bias index score MRL maximum residue limit mRNA messenger RNA MRVIS Mean Running Variance Index Score MS mass spectrometry MSD mass selective detection MSW municipal solid waste MTBE methyl tertiary butyl ether MTC maximum tolerable or acceptable concentration MTD maximum tolerated dose MTE mild toxic encephalopathy MTI N-(hydroxymethyl)-3,4,5,6-tetrahydrophthalamide

NAA neutron activation analysis NAC N-acetyl cysteine NAD nicotinamide adenine dinucleotide NADP nicotinamide adenine dinucleotide phosphate NADPH reduced nicotinamide adenine dinucleotide phosphate NBU N-nitrosobutylurea NCAM neural cell adhesion molecule NCI National Cancer Institute (USA); negative ion chemical ionization NCV nerve conduction velocity ND not detectable NDDC sodium diethyldithiocarbamate NDMA nitrosodimethylamine NDMC sodium dimethyldithiocarbamate NEQUAS National External Quality Assessment Scheme (UK) NFT neurofibrillary tangle ng nanogram (10^-9 g) NIOSH National Institute for Occupational Safety and Health (USA) NK natural killer nm nanometer NMCL nonmelanolic cell lines NMN N-methylnicotinamide NMOR N-nitrosomorpholine NMR nuclear magnetic resonance NNM N-nitrosomorpholine NO nitrogen oxide NOAEL no-observed-adverse-effect level NOEC no-observed-effect concentration NOEL no-observed-effect level NOLC no-observed lethal concentration NPD nitrogen-phosphorus sensitive detector NPSH non-protein sulfhydryl NSAID non-steroidal anti-inflammatory drugs NSD nitrogen selective detector NTA nitrilotriacetic acid NTE neuropathy target esterase NTEL no-toxic-effect level NTP National Toxicology Program (USA) O OCT ornithine carbamoyltransferase ODC ornithine decarboxylase ODP ozone-depletion potential OECD Organisation for Economic Co-operation and Development OEL occupational exposure limit OER oxygen enhancement ratio OES occupational exposure standard; optical emission spectrometry OET open epicutaneous test OP organophosphate OPIDN organophosphate-induced delayed neuropathy OR odds ratio OSC oil-enhanced suspension concentrate OSHA Occupational Safety and Health Administration (USA) OVA ovalbumin OZT oxazolidinethione P PA polyamides PAA photon activation analysis 2-PAM chloride pralidoxine (2-pyridine aldoxime methyl) chloride PAH p-aminohippurate; polycyclic aromatic hydrocarbon PALS periarteriolar lymphocyte sheath PAN peroxyacetyl nitrate; polyacrylonitrile PAS periodic acid Schiff stain PB phenobarbital PBA phenoxybenzoic acid PBalc 3-phenoxybenzyl alcohol PBald 3-phenoxybenzaldehyde PBB polybrominated biphenyl PBDD polybrominated dibenzodioxin PBDE polybrominated diphenyl ether PBDF polybrominated dibenzofuran PBI protein-bound iodine PBPK physiologically based pharmacokinetics PBT polybutylene terephthalate PCBD S-(1,2,3,4,4-pentachloro-1,3-butadienyl) PCDD polychlorinated dibenzodioxin PCDF polychlorinated dibenzofuran PCA para-chloroaniline (4-chloroaniline); passive cutaneous anaphylaxis PCB polychlorinated biphenyl PCBD S-(1,2,3,4,4-pentachloro-1,3-butadienyl) PCDD polychlorinated dibenzo-p-dioxin PCDF polychlorinated dibenzofuran PCDPE polychlorinated diphenylether PCE polychromatic erythrocytes PCOM phase contrast optical microscopy PCPY polychlorinated pyrene PCQ polychlorinated quaterphenyl PCT porphyria cutanea tarda PCV packed-cell volume PD plasma desorption PDG phosphate-dependent glutaminase PE polyethylene PEF peak expiratory flow PEG pneumoencephalography PEL permissible exposure limit PET polyethylene terephthalate PFC plaque-forming cell pg picogram (10^-12 g) PG prostaglandin pH the negative logarithm of the hydrogen ion concentration PHF paired helical filaments PHS prostaglandin-H-synthetase PIB piperonyl butoxide PIC picrotoxin PID photo-ionization detection PIXE proton-induced X-ray emission pKa the negative logarithm of the dissociation constant PMBA p-methylbenzyl alcohol PMN polymorphonuclear leukocyte PMTDI provisional maximum tolerable daily intake PMR proportional mortality rate PMSG pregnant mare serum gonadotrophin PNS peripheral nervous system pO2 plasma partial pressure (concentration) of oxygen POCP photochemical ozone-creation potential PoG proteoglycan POS psycho-organic syndrome PP polypropylene ppb parts per billion ppm parts per million ppt parts per trillion PSD passive sampling device PSPS Pesticides Safety Precautions Scheme (United Kingdom) PT prothrombin time PTH parathyroid hormone PTT partial thromboplastin time PTU propylenethiourea PTWI provisional tolerable weekly intake PTZ pentylenetetrazole PVC polyvinyl chloride PYR pyrene Q QA quality assurance QAP quality assurance programme QC quality control QSAR quantitative structure-activity relationship R RACB reproductive assessment by continuous breeding RAST radioallergosorbent test RBC red blood cell RBP retinal binding protein RDA recommended dietary allowance (USA) REL recommended exposure limit RER rough endoplasmic reticulum RIA radio-immuno assay RIPT repeat insult patch test RMA reflex modification audiometry RNA ribonucleic acid RNI reference nutrient intake (UK) ROC reactive organic carbon RPN renal papillary necrosis RR relative risk RTECS Registry of Toxic Effects of Chemical Substances RUBISCO ribulose 1,5-biphosphate carboxylase S S9 9000 x g supernatant SAM S-adenosylmethionine SAP serum alkaline phosphatase SAR structure-activity relationship sc subcutaneous SC suspension concentrate SCE sister chromatid exchange SCF stem-cell factor SCID severe combined immunodeficiency SCOPE Scientific Committee on Problems of the Environment of the International Council of Scientific Unions SD standard deviation SDAT senile dementia of Alzheimer type SE standard error SEM standard error of the mean; scanning electron microscopy SER smooth endoplasmic reticulum SFC supercritical fluid chromatography SFS subjective facial sensation SGOMSEC Scientific Group on Methodologies for the Safety Evaluation of Chemicals SGOT serum glutamic-oxaloacetic transaminase SGPT serum glutamic-pyruvic transaminase SHE Syrian Hamster embryo SIM selected ion monitoring SIMS secondary ion mass spectrometry SLE systemic lupus erythematosus SMA sequential multiple analyser SMR standardized mortality ratio SOP standard operating procedure SPF specific pathogen free SPM suspended particulate matter S-PMA S-phenyl-mercapturic acid SRT simple reaction time SSB single strand breaks STEL short-term exposure limit T t_3 triiodothyronine t_4 thyroxine 2,4,5-T 2,4,5-trichlorophenoxyacetic acid TADI temporary acceptable daily intake TAN tropical ataxic neuropathy TAP trialkyl/aryl phosphate TBBPA tetrabromobisphenol A TBG thyroxine-binding globulin TBP tributyl phosphate TBPP tris(2,3-dibromopropyl) phosphate TBT tributyltin TBTO tributyltin oxide TCA tricarboxylic acid cycle TCD thermal conductivity detection TCDD 2,3,7,8-tetrachlorinated dibenzo-p-dioxin TCDF 2,3,7,8-tetrachlorinated dibenzofuran TCE 1,1,1-trichloroethylene TCP trichlorophenol; tricresyl phosphate TCPP tris(1-chloro-2-propyl)phosphate TCR T-cell receptor TDC thermal conductivity detection TDI tolerable daily intake; toluene diisocyanate TDLAS tuneable diode laser absorption spectrometry TEA tetraethyl ammonium; thermal energy analyser TEAC tetraethylammonium chloride TEAM total exposure assessment methodology TEF toxicity equivalency factor TEPP tetraethyl-pyrophosphate TGA thermogravimetric analysis TH thyroid hormone THF tetrahydrofolate TI tolerable intake TLC thin-layer chromatography TLV threshold limit value TMCP tri-meta-cresyl phosphate TMDI theoretical maximum daily intake TML tetramethyllead TMRL temporary maximum residue limit TMT trimethyltin TNF tumour necrosis factor TOCP tri-ortho-cresyl phosphate TOD total oxygen demand TPA 12-O-tetradecanoylphorbol-13-acetate TPCP tri-para-cresyl phosphate TPI 3,4,5,6-tetrahydrophthalimide TPIA 3,4,5,6-tetrahydrophthalic acid TPN total parenteral nutrition TPO thyroid peroxidase TPP triphenyl phosphate TPTA triphenyltin acetate TPTH triphenyltin hydroxide tRNA transfer ribonucleic acid TRP tubular reabsorption of phosphate TSH thyroid-stimulating hormone (thyrotropin) TSP total suspended particulate TST temperature sensitivity TT toxicity threshold TWA time-weighted average U UCM urographic contrast medium UCL upper confidence limit UDP uridine diphosphate UDPGA UDP-glucuronic acid UDPGT UDP-glucuronosyltransferase UDS unscheduled DNA synthesis UF uncertainty factor ULV ultra-low volume UNEP United Nations Environment Programme UNICEF United Nations Children’s Fund US ATSDR US Agency for Toxic Substance and Disease Registry UV ultraviolet UVB ultraviolet B V VC vinyl chloride VCAM vascular cell adhesion molecule VER visual evoked response VHH volatile halogenated hydrocarbon VLA very late antigen VLDL very low-density lipoproteins VOC volatile organic carbon compound VSD virtually safe dose VTR vibration threshold v/v volume per volume W WAIS Weschler Adult Intelligence Scale WBC white blood cell WG water-dispersible granule WHO World Health Organization WISN warfarin-induced skin necrosis WP wettable powder w/v weight per volume X XRF X-ray-generated atomic fluorescence XRFS X-ray fluorescence spectroscopy

ZPP zinc protoporphyrin

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