United States Dispensatory 1926 Part II
Compiled by Ivor Hughes

Warburg's Tincture.�This famous remedy, at first a proprietary medicine, afterwards by the voluntary act of its inventor had its formula revealed. A simplified form of it is recognized by the N. F. There is so much testimony as to its extraordinary virtues in the severe remittent and pernicious malarial fevers of India that its powers can scarcely be questioned. After the bowels of the patient in the acutest stage of the disorder have been freely opened, a half ounce of the tincture is given undiluted, all drink being withheld, and at the end of three hours a second half ounce is given in a similar manner. Soon after the second dose a violent, aromatic perspiration comes on, and the fever is usually broken. The remedy is also commended in collapse without organic disease. The formula given by Warburg is as follows: Socotrine aloes 1 Ib.; rhubarb, angelica fruit, confection of Damocratis, each 4 oz. troy; elecampane, saffron, fennel, prepared chalk, each 2 oz. troy; gentian, zedoary, cubebs, myrrh, camphor, agaric, each 1 oz., troy. Digest the whole with 500 oz. proof spirit in a water bath for 12 hours, express, add 10 oz. sulphate of quinia, dissolve by the aid of a water bath, cool, and filter.

It is evident that Warburg's tincture contains various substances which are inert, but the practical difficulty is to determine as to what its extraordinary value anti-malarial powers are really due. The formula used in the U. S. Army, with asserted excellent results in Cuba, has the advantage of yielding a product in tablets, which is as follows: Aqueous extract aloes, 224 grains; rhubarb, 448 grains; angelica seed, 448 grains; elecampane, 224 grains; saffron (Spanish), 224 grains; fennel, 224 grains; gentian, 112 grains; zedoary root, 112 grains; cubeb, 112 grains; myrrh, 112 grains; white agaric, 112 grains; camphor, 112 grains; quinine sulphate, � 1280 grains. Exhaust with eight pints of diluted alcohol, or divide into 1024 tablets.

The confection of Damocratis, in the original, which was a combination of thirty aromatic substances mostly obsolete, may be found in the 19th ed., U. S. D., p. 1695. It is contained in the formula in such small amount that it is hardly possible that it could have any effect. (See also Tinctwa Antiperiodica, N. F., Part III.) The National Formulary has revised the formula of Warburg's tincture and there are two tinctures, one with and one without aloes.

Dose.�The dosage of Warburg's tincture depends on the kind used�whether with aloes or without�and the intended purpose, and varies from 4 cc. (1 fluidrachm) to 15 cc. (4 fluid-rachms). The larger quantity is given when Doctor Warburg's original directions are followed for administering the remedy in remittent fevers. These directions were as follows: " One-half ounce to be given alone, without dilution, after the bowels have been evacuated by any convenient purgative, all liquids being withheld. After three hours another half ounce is to be given."

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