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Earth Air Fire and Water
Introduction We may clearly see, where we were halted, and had to take another road. After all, the urge of the specie is �Survive� That is a primal command. Only 50 years ago things were so very different, in terms of the health and the vigour of the Western style populace at large. We have fallen a long way. Current developments, in the Medical, Biological and Agricultural Sciences, when viewed against the backdrop of where we are as a specie, both ethically and spiritually, is alarming. Our Materia Medica is formed from the accreted wisdom of the past. Untold millennia that recede much further than the evidence of the 60,000 year old Shanidar burial site. The Materia Medica is the peoples heritage, the legacy of the past. A great gift from the Ancestors. It is under threat from those that would take it, and then restrict access. The Materia Medica 8.1
A. Pharmacognosy
However, when the drug plant arrives in the laboratory or pharmacy, it is usually in its dried form, and the task of identification becomes more exacting. It will be appreciated that the dried plant, or plant part, will have a very different appearance to that of the fresh plant, therefore, a good knowledge of plant morphology is essential. Morphology is the study of the plants shape or form, e.g., root, leaf, stem, flower, etc. In the event that the material is grossly distorted from the drying process, or is shattered, granulated or powdered, then knowledge of plant histology is needed. Histology is the study of minute structures of organic tissue. The moderately magnified material, will be compared with a known true sample, and examined for foreign material, and also for evidence of deliberate adulteration. B. Pharmacology C. Toxicology
D. Posology
E. Herbal Apothecary. There are various fragments of materia medica from the ancient Babylonian and Egyptian eras. Examination of the medical recipes show a fine grasp of the knowledge required of a sophisticated system of medicine. It cannot be simply brushed aside, as magical mumbo jumbo. Some of the recipes contained animal and insect parts, while others contained faeces from various sources. In the past it has been the trend, in orthodox medical circles, to dismiss such formulations as gutter or sewer pharmacy, while ignoring the obvious parallel with modern Sera and vaccines. However, today a more enlightened interpretation of the evidence is steadily gaining ground, e.g., �Science and Civilisation in China�. Vol. 5 Chapter 15 Cambridge. The most famous of the Egyptian medical writings, is the so called �Ebers� papyrus, which has been dated Circa 1550 BC. Over 3,500 years old, therefore, we must avoid the trap of confusing technology with intelligence, or considering scientific theory to be superior to empirical knowledge, because clearly it is not.
The
Raw Materia Medica 8.2 Today the rich tapestry has resolved itself into four major strands, A golden thread, where natural medicine is practiced as both an art and a science. Chinese - Islamic - Ayurvedic/Unnani and Neo-Western. The major schools are like beads on a string, elective, both in system and raw materials. Between them they are able to muster around 6,000 plants of known therapeutic activity. No other system of medicine can command such a flexible and wide ranging materia medica. And one that circumvents the modern problem of racial idiosyncrasy. The figure of 6,000 plants must be viewed in context. Of the estimated 250,000 members of the angiospermidae (flowering plants), less than 5% have been screened for medicinal substances. The majority of that 5%, have only been screened for a single substance , e.g., an alkaloid; on that basis alone, we can be assured that, even with a written history of almost 4,000 years, the art is still in its infancy and that, like an iceberg, much lies hidden. All our needs in nature are catered for, if that were not so, we could not have survived as a specie. When a correctly prepared herbal medicine, fails to achieve its goal, it is not the efficacy of the herb, that is called into question, but rather the accuracy of diagnosis and method of treatment. However, that is a problem that is common to all systems of medicine. There is no evidence to suggest that high tech diagnostic techniques achieve a greater accuracy than those obtained by a sensitive natural healer.
Crude Vegetable Drugs 8.3
Table 8.3A Crude Drugs.
All of the above plant parts are classified as �Organised� drugs, in that they have a well defined cellular structure. Another class of crude drugs is the exudations; Table 8.3B The Exudations.
The substances in Table 8.3B, are said to be "Unorganised�, meaning that they do not have a cellular structure. A further important class of substances are the Bee �APIS� products; Honey - Wax - Propolis - Pollen. The honey, wax and propolis, are classed as exudations and have unorganized structures. Pollens, as gathered by bees, are the fertilizing spores of flowering plants, and have an organized structure. The structure of the crude drug will determine its processing route.
The Evaluation of Crude Drugs
8.4
1.Organoleptic Assessment, which is inclusive of the following;
A - Smell - e.g. is it characteristic of
the material? 2. Microscopic Assessment, usually for powdered drugs. Its histological appearance must match that of a known sample, and the % of adulteration with foreign substances noted. 3. Chemical and Physical Testing, physical constants, such as melting points (mp), boiling points (bp), specific gravity (sg), solubility; and optical rotation, such tests are used extensively with drug constituents, e.g., volatile and fixed oils, alkaloids and glycosides. Chemical methods will include thin layer chromatography, ash tests, water and ethanol soluble extractive values, heavy metal tests etc. In these days of increasing specialization, such tasks are no longer performed by the pharmacist. However, they must be able to predict incompatibilities, solubilities and therapeutic dose, and advise in such matters. Herbal Constituents 8.5 The active constituent levels, in the families of plants that contain them, are a function of known variables and from that, a plus/minus % for those levels can be known. It is now recognized that the overall synergy of a plant is more important than the level of a single constituent. Quite obviously, a plant medicine must be standardized in some way, so that a safe functional dose may be prescribed. There are four main methods. 1 - By Chemical Assay � This involves the separation of the known constituents. The concentration is determined and adjusted to a specific potency, based on the original concentration. This totally destroys the synergy of the plant. 2 - By Biological Standardization. - This method is usually reserved for potent drugs, where a chemical assay is not possible or is unreliable, for example, Digitalis, (Foxglove). The assay carried out by utilising the LD. 50 test (Lethal Dose: 50%). A number of experimental animals are used to determine the minimum dose required to kill 50% of the creatures, within a defined period of time. Such tests are not precise, due to the differing metabolism of humans and the animals, and also human idiosyncrasy, as may be observed by the high rate of toxic effects of digitoxin, when administered to patients of the same size and weight as each other. It need hardly be pointed out that this method involves extreme cruelty. The synergy is again destroyed. 3 - By Physical Standardization. - This method is usually combined with the chemical method and takes account of boiling point, melting point and specific gravity. Once again, the level of 1 or 2 known constituents are adjusted to a specified level of activity. The synergy of the plant material is destroyed. 4 - Arbitrary Standardization. - Is carried out by adjusting a liquid extract to volume, whereby 1 millilitre of the extract is equal to 1 gram of the air dried herb. Obviously, the quality of the herb is the only variable when that method is used. The synergy remains intact. Ethical considerations, to one side, and from the standpoint of natural medicine, methods 1, 2, and 3, are not acceptable, because the natural synergy of the herb has been destroyed. It is well known among Galenic Pharmacists, that extracts and tinctures prepared by arbitrary standardization usually display a higher level of activity than would be expected from the known concentrations of the so called active principle. In clinical practice, they also display a more acceptable and predictable pharmacological response than assayed products. A Brief Description of Herbal Constituents and their Solubility's in Alcohol and Water, 8-6 Before proceeding to a description of the carriers and solvents employed in pharmacy, it will be helpful to review the major compound constituents of herbal drugs, and their solubility's in alcohol and water.
Alkaloids
8.7 They are naturally occurring nitrogenous bases, and are combined with acids as salts. So they are said to be �basic� in that they are on the alkaline side of pH7. Some cultures �free base� alkaloids by adding some slaked lime or a substitute to the botanic chewing quid. Alkaloids may be solids or liquids. The majority of the known alkaloids are solids, in addition to nitrogen, they contain carbon, hydrogen and oxygen. Generally, the alkaloids are freely soluble in alcohol or diluted alcohol, but only feebly so in water, however, if the alkaloid has been precipitated as a salt, they become freely soluble. Most of the alkaloids are sensitive to heat. The alkaloid containing drugs should not be exposed to temperatures exceeding 60�C. Therefore, the practice of preparing infusions or decoctions from alkaloidal herbs is a dubious procedure; because the resulting changes may render the alkaloid liable to hydrolysis (decomposition), or it may be converted to an isomeride, which is a compound which has the same kind of atoms, in the same proportions, but are arranged differently. This changes the chemical and physical properties of the original compound. In some cases, both reactions may occur together, thus the synergy is irretrievably destroyed. Anthraquinone Derivatives (Emodins) 8.8 Albumins and Globulins 8.9 Chlorophyll 8.10 Cellulose and Lignin 8.11 Lignin forms the secondary cell wall, which grows when the cell has matured. The primary function of lignin is for stiffening and support, and is present in all shrubs and trees. Cellulose and lignin are insoluble in alcohol and water. Medicinally they are considered to be inert, and are discarded on completion of the extract process. However, the Spagyric School considers that view to be incorrect, and further recover the salts from the cellulose and lignin, which is then added to the final extract. Fixed Oils 8.12 Flavonoids 8.13 Glycosides 8.14 Gum Mucilage 8.15 Resins 8.16 1. The True Resins are usually solids and non volatile, e.g., Colophony and Copal. They are soluble in alcohol and volatile oils, but insoluble in water. 2. Oleo-resins and Balsams. The oleo-resins are a mixture of resin and volatile oils. Those products, which also contain benzoic and cinnamic acids, in addition to the resin, are usually designated as balsams, e.g., copaiba and Balsam of Tolu. They are soluble in alcohol but not in water. 3. The Gum resins form an important group of medicinals, e.g., Asafetida, Galbanum, Gamboge, Myrrh, Olibanum and Scammony. Many of the gum resins also contain volatile oils. The gums are usually completely soluble in water, but insoluble in alcohol. The resins and volatile oils are soluble in alcohol (90%), and insoluble in water. The gums are precipitated from solution by the alcohol. Starch 8.17 Tannins 8.18 Volatile Oils 8.19 Waxes 8.20
Solvents
used for Extraction Purposes 8.21 In chemistry the solvent is known as the �Solution�, and the extracted material as the �Solute�. In Apothecary work, the solvent used for extraction is referred to as the �Menstruum�. When the material has been extracted, the menstruum is known as the �Vehicle�, or �Carrier� of the extracted material. The use of solvents, allows quite precise manipulation of herbal material; without their use, herbal therapeutics would not have advanced far beyond a primitive art. Solvents of various kinds are in widespread use throughout industry and in most households, in the form of stain removers and oven cleaners, washing powder and liquids Solvents differ widely from each other, not only in differing boiling points, but how they act, or react, with substances in which they come in contact. In order to maintain the synergy of herbal preparations, it is vitally important that the plant compounds do not decompose, dissociate or complex, when in contact with a solvent. Basic Chemical Reactions 8.22 Incompatibilities in Herbal Preparations 8.23 Contrary to popular perception, the fate and excretion of a plant drug, when introduced to the biological idiosyncrasy of an individual, is far from settled. The five basic chemical reactions are not limited to the test tube, but are an integral part of our human economy. For those reasons, the Apothecary must view the practice of poly-pharmacy (2 or more drugs), with a critical eye. In the event of an adverse reaction from the administration of a compound remedy, the therapist is faced with the task of eliminating the offending substance, or substances. To prescribe one that is not of an impeccable empirical character, is irresponsible, unethical and could dangerous. Incompatibilities 8.24 A. Chemical. B. Physical. C. Pharmaceutical. D. Therapeutic. Chemical Incompatibilities 8.25
1. A
combination reaction. (glycosides subject
to hydrolysis) As a general rule, herbs should be prepared and prescribed on their own. Poly-pharmacy has long since been discredited, yet herbal preparations of incredible proportions, are still to be found as articles of commerce. It is clearly a contradiction in terms to talk of synergy, when related to a compound preparation of two or more herbs, because the synergy of each is thereby destroyed. The compound complexity of a single herb is such, that it could take a modern research laboratory, years of painstaking analysis to unravel. A classic example would be the combination of an alkaloid and tannin containing herb, which will precipitate the alkaloid. Such a solution will concentrate the alkaloid at the bottom of the preparation. The danger being that a toxic amount of the alkaloid may be ingested in the final 2 or 3 doses. The organic acids, such as benzoic, salicylic and tannic acids, can give rise to the precipitation of alkaloids. Undoubtedly, alkaloids and organic acids are to be found together in a herb, and when extracted alkaloidal precipitation does not occur. This is because all the constituents are in chemical equilibrium. However, the addition of further organic acids, by the combination of another herb of similar properties, may be enough to upset the balance and precipitation occurs. Further changes will also occur from a change in the menstruum. Pharmaceutical Incompatibility
8.26 Physical Incompatibility 8.27 Therapeutic Incompatibility 8.28 Solvents used for Herbal Preparations 8.29
1. It should display low
toxicity to higher life forms.
The following solvents find widespread use
in the manufacture of herbal preparations. In addition orthodox pharmacy makes use of the following; Chloroform.Ether. Light Petroleum. Propylene Glycol. Acetone (dry cleaning fluid) is also used especially with the lactones. The last 5 of the 10 listed solvents have no role to play in herbal preparations, they are dangerous and unethical, therefore, they will not be further discussed. Of the remaining five solvents, by far the most satisfactory is Ethanol, Water and aqueous solutions of Ethanol, in that they most nearly meet the relevant criteria for the extraction of vegetable drugs.
Solvents and Their General Properties 8.30 1. Cider Apple Vinegar, which is made by an alcoholic and subsequent acetous fermentation of apple juice, and contains not less than 4% acetic acid. 2. Glucose Vinegar, which is made by the alcoholic and subsequent acetous fermentation of a solution of glucose, and contains not less than 4% acetic acid. 3. Distilled (Spirit) Vinegar, which is made by the acetous fermentation of dilute distilled alcohol, and contains not less than 4% acetic acid. 4. Malt Vinegar, which is made from an infusion of cereals, or barley malt which has undergone the malting process, i.e., the starch is converted to fermentable sugars by the action of enzymes. The infusion then undergoes alcoholic, and subsequent acetous fermentation, and contains not less than 4% acetic acid. 5. Wine (Grape) Vinegar, which is made by the acetous fermentation of grape wine, and contains not less than 4% acetic acid. It is quite common when consulting herbals, both ancient and modern, to find the continuing advocacy of vinegar, as a solvent of plant drugs (Acetic tinctures). This convention has nothing to commend it. The solvent powers of vinegar are due to its acetic content. Undoubtedly acetic acid is a good solvent of many substances; its use is restricted to a mere handful of official preparations. This because of the destructive effect of the acids on the bio-structure of the herbal material. From a medicinal standpoint, vinegar is of use as a local astringent, and internally as a blood cleanser, cider vinegar being a case in point. The chief impurities found in vinegar, possibly due to incorrect manufacturing methods, are copper, tin, lead and sulphuric acid. The essential constituents of vinegar are water and acetic acid, however, different types of vinegar will also contain traces of substances that are derived from the starting liquor. These substances will produce differing physiological effects. Vinegar is prone to putrefaction and decomposition when exposed to air. For those reasons, it has been replaced by dilute acetic acid in all national pharmacopeias. The acetic acid of commerce, is produced by various industrial processes. The most common being by the destructive distillation of wood, which yields a crude product called Pyroligneous Acid, which when purified, yields the acetic acid of commercial strength. Description and Physical Properties 8.32 Diluted Acetic Acid (Acidum Aceticum Dilutum 6%), 8.33 B.P.V - Acetic Acid 152.6 gm; Distilled Water, sufficient to produce 1000 ml. Mix. USP X - Acetic Acid 165 gm; Distilled Water 835 gm, to make 1000 gm; Mix them. The official preparation is approximately 6% acetic acid, in comparison with the 4% of commercial vinegars.
Acetic
Acid as Solvent 8.34
In the human body, fats
and oils are
decomposed by pancreatic secretions
in the small intestine, to yield fatty acids and glycerine. Commercially three
grades of glycerine are recognized; * Pure or purity are relative terms. Absolute purity in the synthetic
sense, does not exist.
However,
distinction must also be made between that which is produced (within the
organism), and that which is produced synthetically. Large oral doses of glycerin are
toxic, and like ethyl
alcohol, precipitates and dissolves pepsin from the mucin layer of the
stomach. The derivatives of
glycerin are numerous, e.g., the explosive nitro-glycerin. The congeners of
glycerin are far more toxic than the parent compound, two of which,
diethylene glycol and monoethyl ether, exert a nephrotoxic action. Oral administration of
drugs dissolved in diethylene glycol have resulted in deaths. Glycerin, at
one time, enjoyed widespread use in pharmacy as a vehicle for internal and
external use. It was also used by the pharmacist as a convenient excipient,
or binding agent, for pills of a dry powdery nature. Pharmaceutical grade glycerin
is usually taken to mean 95% anhydrous, i.e. 95%
glycerin and 5% water, and
like ethyl alcohol, was used in various dilutions according to its end use.
For example, it was at one time recommended as a preservative for Galenical
preparations. Presumably, because of its non-fermentability, and the fact
that it was cheaper than alcohol, not being subject to excise duty. However,
subsequent tests showed that it took four days exposure
to 50% glycerin
to destroy non sporulating organisms, and that spore forming bacteria were still viable
after a 15 day exposure. It is often stated that
the glycerin is a good solvent, however, that statement must be placed in
context. Glycerin is a good solvent of alkalies, and the alkaline earths,
from which a large class of orthodox medicinal substances are produced, of
which, the most important are; Ammonium, Barium, Calcium,
Magnesium, Potassium and Sodium.
In addition, it will dissolve iodine and a large number of the
neutral salts. The action of glycerin
on vegetable substances is deleterious, and produces heavy precipitation of
herbal components. There is, however, one notable exception,
and that is components of the tannins,
where it is believed that the addition of glycerine prevents the decomposition
of the
phlobatannins into phlobaphenes.
In the first decades of
the 20th century, glycerin containing galenicals were to be found
in all national pharmacopeias. It is worth noting that the glycerin
containing menstruum�s, were gradually replaced by hydro alcoholic solvents
until many of the galenicals were themselves replaced by synthetic drugs. Over filtration of galenicals is discouraged
by reason of excessive removal of actives from the carrier fluid, however,
having prepared many of the glycerin containing galenicals, it is virtually
impossible to avoid double and triple filtration, if one wishes to produce a
clear bright liquid which is devoid of precipitation. The precipitate present
on the filter papers is heavy. The filter papers were washed with water;
dilute alcohol and alcohol, in an attempt to return the precipitate back to
solution. This was not, successful, the changes involved in the precipitate
were not reversible, i.e. the changes were chemical rather than physical.
The inevitable conclusion is, that the integrity and synergy of the product
is compromised. It is therefore, regrettable to find that many glycerine
containing substances are still being marketed to the natural therapies
sector for medicinal purposes. Water (Aqua) 8.36 Yet, it has intrinsic properties
which cannot be explained by such simplistic formula; indeed, it behaves in
ways that defy scientific explanation. Hermetic science, or alchemy,
allocated a special branch to the alchemy of water, so great an importance
did they attach to its source, collection and distillation. They called
water �the universal solvent�, or mother of life. Pure water is
transparent, colorless, tasteless and without odor. Its boiling point
at standard pressure (760 mm Hg), is 100�C,
and freezing point
is 0�C. At 4�C, water is at its
greatest density. When its
specific gravity is taken to be unity or 1.000. At 4�C. One cubic centimeter
(1ml) weighs one gram. Its specific gravity at
4�C, is the reference point
for all other liquids and solids. If water is ingested at
a greater rate than it is excreted it becomes toxic. The condition is known
as �water
intoxication�. The symptoms
are cerebral oedema, muscle tremors and convulsions. Water intoxication can
occur due to kidney failure or febrile heart conditions. The solvent powers of water are formidable,
it dissolves all known gases, most solids, and is miscible with many
liquids. As a solvent, it has many advantages;
1. It is generally nontoxic.
A. Because
of its wide solvent powers, it is not selective
and many organic substances will decompose, grow or ferment when in
contact with it. B. Hydrolysis of glycosides
is common with subsequent enzyme action,
which is undesirable. C. Water promotes
the growth of
micro-organisms, many of
which, aside from assisting spoilage, can be extremely toxic. D. Because of it high boiling
point, concentration of
preparations made from it, can only be achieved at a temperature
that decomposes most bio-active substances. In all medicinal preparations
where water is designated as the menstruum, either in total or in part, then
water should be taken to mean �distilled water�.
The reasons will become clear in the ongoing discussion. Classes of Water 8.37 Our environment contains
in excess of 500,000 highly toxic, man made compounds. We have no means of
knowing what the
implications for the bio-sphere are; still less do we understand the
chemical interaction of these compounds with each other. Quite clearly,
if we add contaminated water to the compound complexity of a medicinal
plant, and then add that to the compound complexity of the human system,
then we have no
means of predicting the
outcome. Many herbals,
both ancient and modern, quite often direct that infusions and decoctions be
prepared with rain
water, or more popular �Spring Water�.
In point of fact,
such terms are meaningless,
we first define whether rain water
is to be collected from
coastal areas, rural
areas or industrial areas. In the case of spring water,
the strata through which the spring rises
must be defined. Clearly there are many variables involved in quality and
composition of water, irrespective of where it is collected, so in a sense,
there are many varieties of water, some of which are now briefly mentioned. Rain Water 8.38 These contaminants are
distributed globally on stratospheric currents. Because of its solvent
powers, rain water contains appreciable amounts of dissolved atmospheric
gases. It contains
chlorine, ammonia, nitrogen,
while that which falls over cities, contains nitrogenous organic matter. The
rain that falls on
coastal districts, also
contains chlorides
(salts) of various kinds.
The amount of substances precipitated, increases considerably during
thunderstorms, no doubt due to the massive electrical discharges visible as
lightning. Reservoir and Lake Water 8.39 The water is passed through filter beds
to remove the suspended organic matter, then to
kill any pathogenic bacteria,
the water is
chemically treated, usually
with chlorine.
Some areas also add
fluoride to the water. It
then passes through the water main, through the individual plumbing systems,
and generally emerges as clear water from the tap. This clear water contains
chemicals, heavy metals and is well seasoned with dead bacteria. River Water 8.40 Spring Water 8.41 Therefore, spring water
depends entirely, for its content and quality,
on the strata
through which it rises. If
it rises through limestone it will be hard water. The carbon dioxide in the
water reacts with the calcium carbonate of the limestone, to produce
bicarbonate. Spring water is usually softest and purest
where it rises through strata of granite, gravel
or siliceous sand. The
following salts are those most commonly found in spring water;
Artesian
Wells 8.42
Distilled water, upon standing
for long periods in glass containers, will
dissolve minute quantities
of the glass;
in addition, it has the same properties as common water in promoting the
growth of micro-organisms. Wherever possible, it should be freshly prepared
and correctly
stored on a weekly basis.
The manufacture of distilled water will be dealt with in the section headed
�Preparation of Solvents�.
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